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Performing music requires auditory and visual perception skills, attention, precise timing, extended control over movement, learning, memory and emotion 1, 2, 3, 4, 5. Music performance (typically playing an instrument) is a complex cognitive function of the human brain, whose biological basis is largely unknown. For the first time, this study provides evidence for the candidate genes and molecular mechanisms underlying music performance. Additionally, modulation of genes related to calcium ion homeostasis, iron ion homeostasis, glutathione metabolism and several neuropsychiatric and neurodegenerative diseases implied that music performance may affect the biological pathways that are otherwise essential for the proper maintenance of neuronal function and survival. Particularly, candidate genes such as SNCA, FOS and DUSP1 that are involved in song perception and production in songbirds, were identified, suggesting an evolutionary conservation in biological processes related to sound perception/production. The up-regulated genes were found to affect dopaminergic neurotransmission, motor behavior, neuronal plasticity and neurocognitive functions including learning and memory.
#The klub 17 music player professional
Here, we investigated the effect of music performance on the genome-wide peripheral blood transcriptome of professional musicians by analyzing the transcriptional responses after a 2-hr concert performance and after a ‘music-free’ control session. However, the molecules and molecular mechanisms involved in music performance remain largely unexplored. Several neuroscientific studies have demonstrated that the brains of professional musicians and non-musicians differ structurally and functionally and that musical training enhances cognition. Music performance by professional musicians involves a wide-spectrum of cognitive and multi-sensory motor skills, whose biological basis is unknown.